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Qaisar et al., 2016

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In type 1 diabetes , a number of autoantibodies are thought to circulate including those which target glutamic acid decarboxylase

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Results: TG-IRE1 mice treated with ip DOX for 4 hrs had a 2.6-fold increase in hepatic IRE1 gene expression (P 90% reduction in hepatic gene expression of Cyp7a1 from 1.13+/-0.63 to 0.1+/-0.06 (P 65 years appear less likely to undergo curative treatment, particularly liver transplantion, and experience higher hazards of mortality